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Diminution des concentrations plasmatiques de fentanyl par augmentation de son métabolisme hépatique par la rifampicine.Re: Truly Freaked Out!! Fentanyl OD or W/D, Unsure! Need Guidance!! I am a little bit involved in your case. To me it feels like you may not be that opiod tolerant and also you are experiecing some side effects that a lot of peo